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Abstract

REVIEW ARTICLEmiRNAs Expressions and Interaction with Biological Systems in Patients with Alzheimer`s Disease. Using miRNAs as a Diagnosis and Prognosis Biomarker by Silvius I. Negoita, Dorel Sandesc, Alexandru F. Rogobete, Madalina Dutu, Ovidiu H. Bedreag, Marius Papurica, Muhammed F. Ercisli, Sonia E. Popovici, Raluca Dumache, Mihai Sandesc, Anca Dinu, Adriana M. Sas, Denis Serban, Dan Corneci

Background: A high percentage of patients develop Alzheimer`s disease (AD). The main signs are loss of memory and cognitive functions which have a significant impact on lifestyle. Numerous studies have been conducted to identify new biomarkers for early diagnosis of patients with AD. An ideal biomarker is represented by the expression of miRNAs. In this paper, we want to summarize expressions miRNAs in AD. We also want to present the pathophysiological and genetic interactions of miRNAs with protein systems in these patients.
Methods: For the study, we examined available studies in scientific databases, such as PubMed and Scopus. The studies were searched using the keywords "miRNAs expression", "Alzheimer`s disease", "genetic polymorphisms", and "genetic biomarkers".
Results: For the assessment and monitoring of patients with AD, the expression of miRNAs can be used successfully due to increased specificity and selectivity. Moreover, the expression of miRNAs can provide important answers regarding possible genetic interactions and genetic therapeutic regimens.
Conclusions: For the evaluation and non-invasive monitoring of patients with Alzheimer`s disease the expression of miRNAs can be successfully used.

DOI: 10.7754/Clin.Lab.2017.170327